Fabrication of Nd3+ and Yb3+ doped NIR emitting nano fluorescent probe: A candidate for bioimaging applications

The intentional design of rare earth doped luminescent architecture exhibits unique optical properties and it can be considered as a promising potential probe for imaging applications. Calcium fluoride (CaF 2 ) nanoparticles with optimum concentration Nd 3+ Yb sensitizer activator, respectively, were synthesized by wet precipitation method characterized x-ray diffraction (XRD) photoluminescence. In spite the fact that energy transfer takes place from to , luminescence intensity was found weak due lattice defects generated doping trivalent cations (Nd divalent host (Ca 2+ ). These defect centres tailored via charge compensation approach co-doping Na + ion optimizing its heat treatment duration. CaF 5 mol% 3 4 after h exhibited significantly enhanced emission life time. ex vivo fluorescence experiment done at various thickness chicken breast tissue. maximum theoretical depth penetration NIR light calculated value is 14 mm. fabricated phosphor serve contrast agent deep tissue near infrared (NIR) imaging. • We have successfully prepared → system. Defects in :Nd /Yb are repaired co-doping. property particles been tuned process. Ex confirms feasibility